A radio station I worked at before had one of these, but, I always felt it was under-utilized as it had very subtle settings dialed in for the processing. And now, I finally got around to investing in one for myself to improve my home studio output, and I couldn't be happier to maximize it for my particular voice.
I plugged this into my signal chain as soon as I got it out of the box, and used it right away to record a commercial VO. It sounded like I was finally maximizing my mic's potential, and I enjoyed the "fuzzy" analog tone I was getting from it.
Up until today, I was relying on plug-ins in post to "mold" the right tone in for my VO work. The 286s now helps me do that as I record, saving me time and effort.
It can get a little tricky trying to find the "right" processor settings for your voice, but a little Googling brings up useful tips on better understanding of what each dial actually does and some good baseline settings. The only drawback is that you can't make presets for different mics. I guess taking a picture of your best settings for each mic would help.
Oh yeah, like a lot of folks, I also wish it had an actual power switch. I would recommend hooking it up to an automatic voltage regulator to keep it from ever getting fried by electrical spikes.
Overall, it's a really great add-on to your gear if you've been hooking your mic up directly to a USB interface. And you won't have to break the bank to get it.
P.S. The folks at Thomann give awesome customer service. They shipped it well and fast, and their chat support is very friendly and helpful.